Conducting Polymer- Hydrogel Blends for Electrochemically Controlled Drug Release Devices

نویسندگان

  • Rosângela C. Barthus
  • Luiz M. Lira
چکیده

Blendas formadas pela polimerização eletroquímica de pirrol em matriz de acrilamida (hidrogel) foram utilizadas, neste trabalho, como dispositivos para a liberação controlada de drogas. A influência de vários parâmetros nesta síntese, como tipo de matriz de hidrogel e condições de polimerização, foi estudada empregando-se planejamento fatorial fracionário. O objetivo final consistiu na obtenção de um material adequado para liberação baseada no controle de potencial. Para os testes de liberação foi utilizada Safranina, como substância modelo. As curvas de liberação demonstram a potencialidade do uso de tais dispositivos. Estes dispositivos foram também caracterizados por espectroscopia Raman e voltametria cíclica.

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تاریخ انتشار 2008